Regional Myocardial Perfusion and Glucose Metabolism in Experimental Left Bundle
نویسندگان
چکیده
Background. Several authors have reported cases in which 20`TI scintigraphy demonstrated perfusion abnormality in the septum of patients with left bundle branch block (LBBB) and normal coronary arteriogram. The mechanism of this abnormality, however, remains to be clarified. Methods and Results. To determine whether LBBB itself induces abnormal myocardial perfusion and ischemia and to elucidate its mechanism, we used an in vivo animal model. LBBB was induced by right ventricular pacing in 17 open-chest dogs. We examined myocardial perfusion and glucose uptake using 201T1 and 18F-labeled 2-fluoro-2-deoxy-D-glucose. 201T1 activity in the septum was reduced to 74.7±14.5% of its maximal activity, and mean activity was 86.5 ±5.3% in the free wall (p <0.05). `8F activity in the septum
منابع مشابه
Regional myocardial perfusion and glucose metabolism in experimental left bundle branch block.
BACKGROUND Several authors have reported cases in which 201Tl scintigraphy demonstrated perfusion abnormality in the septum of patients with left bundle branch block (LBBB) and normal coronary arteriogram. The mechanism of this abnormality, however, remains to be clarified. METHODS AND RESULTS To determine whether LBBB itself induces abnormal myocardial perfusion and ischemia and to elucidate...
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